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Microglia Polarization From M1 to M2 in Neurodegenerative Diseases

Critical knowledge gaps continue to impede the development of more effective interventions

Our findings demonstrate that this mucoadhesive, nano-enabled system successfully overcomes the primary bottleneck of conventional therapies (the blood-brain barrier) leading to significantly enhanced neuro-restoration, reduced oxidative stress, and suppressed neuroinflammation in a PD model

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Therefore, identifying drugs or targets activating Shh signaling pathway may exert neuroprotective effects by inhibiting microglial activation and reducing inflammation following OGD/R injury or cerebral ischemic injury