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Subsequently, Roitt et al.(6) observed that a precipitate formed when an extract of human thyroid gland was added to serum from a patient with Hashimoto's thyroiditis

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The expression of some paternal genes that shouldn't be expressed leads to Prader-Willi syndrome and can be caused by one of the following factors: Absence of paternal genes on chromosome 15

The reason is because the biochemical transformation process is not working properly, usually due to lack of these needed vitamins