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Although often presented as a broadly beneficial polyphenol, resveratrol has also been repeatedly flagged as a potentially PAINS-susceptible molecule, owing to its redox activity, metal-chelating properties, and tendency to interfere with multiple assay formats in a non-specific manner as highlighted in the Nature commentary ( Weight of evidence: Overall evidence is Low : an add-on signal on hyperactivity without core-symptom change

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Demographic differences and trends of vitamin D insufficiency in the US population, 19882004

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Reducing A plaque counts in mice elicits an improvement in sleep cycle restoration, as well as natural fluctuations in A levels, thereby implying that sleep may be disturbed directly by A deposition (Roh et al., 2012)