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Komives presented a comprehensive review discussing the utility of HDX-MS in discovery of IDRs in proteins, monitoring coupled folding and binding, and characterization of protein aggregates and oligomers ( 2.13.2 Ion mobility-mass spectrometry (IM-MS) Ion mobility-mass spectrometry (IM-MS) is an analytical technique that separates ions based on their collision cross-section (CCS, which is a measure of the size and shape of ion that defines its collision rate) in the gas phase