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17 Injured hepatocytes release soluble factors that activate HSCs to differentiate into myofibroblastic HSCs, as evidenced by cellular enlargement and proliferation, an increase in rough endoplasmic reticulum, loss of vitamin A droplets, expression of actin filaments, and increased expression of fibril-forming collagen types I, III, and V

Growth hormone secretagogues: history, mechanism of action, and clinical development

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Age-Related Declines in GH: As people age, natural GH levels drop