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Retinol has a dual effect here: Not only does it decrease the amount of collagen breakdown from sun exposure by blocking the increase of collagenase, but it also helps to stimulate the production of new collagen

The goal is not to overdose, but to avoid deficiencies, especially during periods of fatigue, stress, or unbalanced diet

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Advances in metabolomics, proteomics, and redox-sensitive imaging may provide mechanisms to achieve this objective, although their clinical applicability requires further validation [79]