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Gastrointestinal side effects, including nausea, vomiting, and diarrhea, are extremely common with GLP-1 therapy and may exacerbate nutritional deficits while directly contributing to feelings of unwellness and fatigue

More serious risks include pancreatitis, gallbladder disease, and potential thyroid C-cell tumors (observed in rodent studies)

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Injection typically is only once per day, but where a person is first trying the drug and judging tolerance, injection may be divided into two smaller amounts per day

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