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Overusing injections or receiving them too frequently without medical supervision may not provide additional benefits and could increase the risk of side effects

Lipohypertrophy can change your pharmacokinetic profile unpredictably, making timing optimization pointless because you no longer know how fast the drug is reaching your bloodstream

Overall Evidence for the Use of B12 for Painful Peripheral Polyneuropathy Taking into account the above evidence, there is level III evidence overall to support the use of B12 either as monotherapy or as a combination therapy for treating neuropathic pain caused by peripheral polyneuropathy

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B12 also plays a role in helping the nervous system function properly and in red blood cell maintenance, repair, and formation