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Jutley, and MW Holliday Jr report no conflicts of interest in this work

There is an extensive literature based on data from pre-clinical and clinical studies that indicates metformin protects endothelial function from the effects of diabetes (33)

Cell viability Cellular viability was evaluated by a CCK-8 proliferation assay using a Cell Counting Kit-8 (Nanjing Jiancheng Bioengineering Institute, China)

Frazer, L.C

Instead, speak to a healthcare professional to: Help manage the side effects Change the prescribed dose Use the medication as part of a comprehensive weight management strategy