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Recently, a stromal atlas constructed from four chronic inflammatory diseases revealed the existence of two major fibroblasts subpopulations, the CXCL10 + CCL19 + inflammatory fibroblasts, and the SPARC + COL3A1 + perivascular fibroblasts ( Irrespective of which specific receptor mediates the actions and what intracellular signalling mechanism may be involved, it has been demonstrated that MC drugs are generally safe for their use in humans (135)

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Likewise, in dose and application regimens as described before heparin (Belupo, Croatia), warfarin (Martefarin (Orion Pharma, Finland)), L-NAME (Sigma, USA) and L-arginine (Sigma, USA) dissolved in saline were used as well [1,14,15]

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