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These include uncertainties regarding long term biocompatibility, potential toxicity, and accumulation of nanomaterials in tissues

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For instance, while ultrasound-targeted microbubble destruction (UTMD) systems for GDNF or BDNF gene delivery show synergistic neuroprotective effects in PD models, simultaneous GDNF/BDNF delivery did not show additional benefits, possibly due to competing expressions (Lin et al., 2020)

Additionally, NAD+ supplements have shown some benefits in treating and preventing some neurodegenerative diseases such as Alzheimer's disease

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