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In addition to effects directly on the activity of BCKD, the inhibition of MPC leads to activation of AMPK with the result being alterations in various metabolic processes that, in turn, reduce the level of phosphorylation of BCKD with the consequences being increased metabolism of BCAA

Introduce Tretinoin slowly into the routine, beginning with every other night

Contingent on promising early results, a major clinical trial (Phase 3) is conducted with hundreds to thousands of patients to confirm the treatments efficacy

PMID: 9141536

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