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The experimental model employedL5L6 spinal nerve ligationis a well-established paradigm that recapitulates key features of clinical neuropathic pain, including mechanical allodynia, and offers high predictive validity for therapeutic response (Kim and Chung, 1992

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doi: 10.3390/medicina55060233

Lancet 372:146372 Dodd S, Maes M, Anderson G, Dean O, Moylan S, Berk M (2013) Putative neuroprotective agents in major psychoses