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When a leaky gut is present, intestinal barrier permeability is increased, pro-inflammatory substances like LPS may activate inflammatory pathways, be recognized and activated by the TLR4 receptor, and mediate inflammatory responses

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Remarkably, tryptophan is metabolically processed through the kynurenine pathway to produce nicotinamide adenine dinucleotide, which is essential for the mitochondrial redox balance (116)

PMID: 30709742 Title: Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity Product/Service Type: Biochemicals Science , 364(6436): pii: eaav0748