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Sielatycka, K., et al

Weekly Injection Schedule After the first phase, shots are given weekly for a few weeks

Researchers became interested when early trials demonstrated unprecedented efficacy in metabolic controlwith some studies showing nearly 30% of subjects achieving normoglycemia and over 20% average weight losseffects that suggested the dual incretin approach might unlock mechanisms beyond what single-target agonists could achieve

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By tailoring each dose adjustment to the patient's specific progress and side effects, the guiding principle is to find the lowest effective dose that comfortably sustains long-term results, rather than rushing to the maximum dose in the shortest time possible