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Staff writers Alison McCook and Harold Brubaker contributed to this article.
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Coexistence of symptoms of depression and low vitamin B 6 status (plasma PLP concentration 20 nmol/L) has been reported in a few cross-sectional studies (73, 74) and one longitudinal study (study used a higher PLP cutoff of 50 years) Early metabolic studies indicated that the requirement for vitamin B 6 in older adults is approximately 2 mg daily (132)
But the mechanistic logic is solid, and the phase 2 weight loss numbers are higher than anything tirzepatide produced in its own trials
