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A recent metallomic study has found significantly lower cortical lithium (Li) in mild cognitive impairment and AD with selective sequestration of Li within amyloid plaques, implying an early disturbance of endogenous Li homeostasis in vulnerable cortex while serum levels remain unchanged
This also results in the opening of the mPTP leading to uncontrolled ROS production and disrupted synaptic maturation causing autistic behaviors [127]
Choose Injectable Delivery When: Maximum bioavailability and systemic distribution are required Your peptide has a molecular weight exceeding 6,000 Da Precise dosing and reproducible pharmacokinetics are necessary Youre using peptides for bodybuilding or muscle growth The peptide lacks CNS targets Choose Nasal Delivery When: Direct CNS delivery and blood-brain barrier bypass are therapeutic objectives Your peptide is small (under 6,000 Da) and shows adequate nasal bioavailability Rapid onset of action (minutes) is clinically valuable Patient compliance and comfort are primary concerns Youre using neurological peptides like Semax or Selank The FDA has approved several intranasal peptide formulations, including ZAVZPRET for acute migraine treatment, validating this delivery route as pharmaceutically viable
Figure 6 Crystal structures of IRAP were recently solved (Hermans et al., 2015
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