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Researchers aren't exactly clear why the drug appears to work better in people with overweight or obesity (but not diabetes) compared to people with diabetes who also have overweight or obesity

What has been shown in humans is the outcome rather than the mechanism

The cloning and expression of a murine triacylglycerol hydrolase cDNA and the structure of its corresponding gene

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Initial Dose : Start with 50 mg (0.5 mL) subcutaneously once weekly for 4 weeks