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(Eur J Endocrinol 1998) reported that ipamorelin stimulated GH release from anterior pituitary somatotrophs via GHSR-1a (Gq/11PLCIP pathway) at doses up to 200-fold its GH-effective dose without significantly elevating ACTH, cortisol, FSH, LH, prolactin, or TSH above GHRH-stimulated controls in rats

Ipamorelin binds to ghrelin receptors in the brain, signaling the body to increase growth hormone release without significantly affecting other hormones such as cortisol or prolactin, unlike older GHRPs

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