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The diagnosis of Melanotic Macules of Oral Mucosa may involve the following procedures: The diagnosis is usually made by a complete physical (oral) examination and evaluation of medical history and family history Skin biopsy: A skin biopsy is performed and sent to a laboratory for a pathological examination, who examines the biopsy under a microscope

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For normal phenotype mice, age-matched C57BL/6 J mice were used