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Although some authors assume the ADA definition (70 mg/dl), GOSEEN, as an expert group, as well as the majority of authors, agrees with using thresholds lower than 60 mg/dl or 3.3 mmol/l, especially after provocation tests, or less than 50 mg/dl or 2.8 mmol/l, when it is spontaneous6,1619

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Previous studies have suggested that IF may induce mild mitochondrial stress, leading to improved mitochondrial function and reduced ROS generation over time 37