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Since both oxidative stress and psychological stress can trigger the collapse of HF-IP to cause alopecia areata, the relationship between these two factors needs to be explored

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Glutathione peroxidase 4-catalyzed reduction of lipid hydroperoxides in membranes: The polar head of membrane phospholipids binds the enzyme and addresses the fatty acid hydroperoxide group toward the redox center

Copper Metabolism Concerns Copper metabolism concerns represent theoretical risk of copper accumulation with prolonged use, though no documented cases of copper toxicity at recommended doses exist in literature

Watermann and Dringen 2023