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Shalita et al 41 found that patients with inflammatory acne showed significant improvement in acne severity and appearance when a combination of nicotinamide, azelaic acid, pyridoxine, copper, and folic acid was added to existing acne regimens at both four and eight week follow up

Their use in non-diabetics has risen by a staggering 700% in the US between 2019 and 2023.2 Despite its popularity, barriers exist high costs, limited supply, and lack of a structured multidisciplinary obesity programs make their use challenging for many patients

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Numerous observational studies have identified a pervasive dysregulation of lipid metabolism in patients with psoriasis, and our research has also discerned a causal link between 13 lipid metabolites and the onset of psoriasis