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Obesity exacerbates diastolic dysfunction and ventricular stiffness, which are the primary contributors to HFpEF.27 Nonetheless, this result showed significant heterogeneity, suggesting variation throughout the study

Decrease in blood pressure by inducing vasodilatation and natriuresis

Liver The ESSENCE trial : resolution of fatty-liver inflammation (MASH) in roughly 63% of treated patients

Overweight individuals who want to shed excess pounds and dont mind implementing a few lifestyle changes make great candidates for this medication

These effects are generally mild with well-formulated preparations but can become significant with certain absorption enhancers