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However, LVF triple therapy is not recommended as a first-line choice for most patients because resistance to LVF is increasing worldwide, but in areas of low LVF resistance and high CLR and MTZ resistance or unavailability of bismuth, this therapy can be used (OMorain et al

doi: 10.1007/s40264-013-0048-4

But Lilly said 11% of participants on the highest retatrutide dose quit the study because of gastrointestinal side effectsa bigger dropout rate than for less powerful obesity drugs