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Based on the aforementioned studies, fluoxetine may negatively affect male reproductive function, especially among androgen-deficient patients who are undergoing fluoxetine treatment for depression

10.1016/j.biopha.2017.10.155 [DOI] [PubMed] [Google Scholar] Zhang X, Yu M, Yu W et al (2009) Development of alopecia areata is associated with higher central and peripheral hypothalamicpituitaryadrenal tone in the skin graft induced C3H/HeJ mouse model

Its tolerability is regarded as well-characterized in the published literature, with no significant off-target hormonal stimulation reported at standard study doses

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