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Skye is conducting a Phase 2 clinical trial ( ClinicalTrials.gov: NCT06577090 ) in obesity for nimacimab, a negative allosteric modulating antibody that peripherally inhibits CB1

Dose-Dependent Adverse Event Patterns One of the clearest findings from published retatrutide data is the dose-dependent relationship with adverse events: Lower doses (1 mg): GI event rates only modestly above placebo Mid-range doses (4-8 mg): GI event rates of 57-64%, with dose escalation reducing peak incidence Highest dose (12 mg): GI event rates of ~67%, though most events were mild-to-moderate and transient The Phase 2 trial included both "single-dose" and "escalated-dose" cohorts for the 4 mg and 8 mg groups

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