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Okayasu et al

Metrics for glycemic control show that semaglutide is the best at lowering HbA1c because it directly increases insulin production

The FDA's approval of oral Wegovy represents a significant step toward broader GLP-1 access, though affordability remains a barrier for many

It has demonstrated enhanced pharmacological efficacy compared to native amylin for reducing food intake and body weight in rodents [111]

Conclusions/interpretation In well-controlled metformin-treated type 2 diabetes, glucose-lowering by metformin is greater when it is given before, rather than with, enteral glucose, and this is associated with a greater GLP-1 response