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Most clinicians would recommend maximizing results with a single agent before adding complexity, particularly given that tirzepatide already produces substantial fat loss on its own

The STEP (Semaglutide Treatment Effect in People with obesity) trial program showed average weight loss of 15-17% of total body weight over 68 weeks, with about 70% of participants achieving at least 10% weight loss and 50% achieving at least 15% weight loss

Reported effects in human use are generally mild injection-site reactions, lightheadedness, fatigue, nausea

Glucagon-like peptide-1 receptor-based therapeutics for metabolic liver disease

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