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Among patients who develop neurotoxicity, some spontaneously recover over months after the end of treatment, while others may develop irreversible peripheral axonal damage, and this different individual susceptibility is essentially unexplained

J Clin Endocrinol Metab (2013) 98(2):35563

Some research suggests these medications may reduce inflammation and improve insulin signaling in the brain, which are mechanisms believed to play a role in neurodegenerative diseases