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DFU: pathogenesis and Microbiome interactions DFUs are a leading example of chronic wounds, arising from neuropathy, impaired vascularization, and persistent hyperglycemia

It was first isolated from human plasma by Loren Pickart in 1973 and has since been studied across wound healing, skin regeneration, bone repair, and hair growth applications

These nonseroconverters include people on B-cell-depleting therapy or people with inborn errors of immunity, as these individuals are typically more susceptible to prolonged infection and higher rates of progression to severe disease [36, 37]

This might cause flushing, irritation, or even excess oiliness

Sci Rep 16 , 4966 (2026)