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Although both HL and LPL are the major lipases in human PHP, in contrast to LPL, HL activity is increased in the presence of high salt and does not require further activation by circulating serum-derived factors (Figure 3B), and in LPL-enriched HR fractions isolated from cell lines that abundantly express and secrete LPL (BV-2 murine microglia) (Figure 3C), even in the presence of synthetic ApoC-II peptide or human serum as a source of ApoC-II