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Phase 2 obesity trial (NEJM, 2023), retatrutide produced a mean body-weight reduction of up to 24.2% at 48 weeks in the highest-dose cohort, following a 2 mg starting dose escalated every four weeks to 12 mg weekly [1][2]

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GLP-1-based therapy was developed in the 1990s and treatment with daily injectable GLP-1 receptor agonists and oral dipeptidyl peptidase-4 (DPP-4) inhibitors was introduced in the 2000s [2]

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