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When to Expect Plateaus and How Genetics May Influence Response Variability Weight loss plateaus are common around weeks 16-20 as the body adapts to appetite suppression and calorie restriction

The framework calls for follow-up labs at four to six weeks and then every eight to twelve weeks through the first year

Click here to listen to this article Share via Key Facts The Rule of 20-30%: In typical weight loss, approximately 20-30% of mass lost is lean tissue (muscle/bone/water), not just fat

Dose escalation should follow the prescribed schedule , as rushing to higher doses increases the likelihood of side effects