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The synthetic ingredient higenamine is not a legal dietary supplement, although it may appear naturally in a variety of plants including Nandina domestica, which is commonly used in throat lozenges in Japan

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In contrast, under the same experimental conditions, 10% DMSO exhibited pronounced cytotoxicity towards both HeLa and HEK293 cell lines, due to its ability to induce cellular stress by developing reactive oxygen species

While 45S5 BG filler particles had irregular shape, the inherent 210 nm porosity of the Cu-MBGN particles seemed to contribute to the resin penetration within the porosities, locking it in the porosities after polymerisation