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Continuous MT-1 administration beyond 3 weeks causes melanocortin receptor desensitization, where melanocytes downregulate MC1R surface expression in response to sustained agonist binding

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doi: 10.1007/s00401-007-0274-x 120

In the TRIUMPH-4 trial, discontinuation rates due to adverse events ranged from 12.2% to 18.2% with retatrutide

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