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High blood sugar, possibly extreme and associated with diabetic acidosis, coma, or death, has also been reported in patients treated with Seroquel

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Increased Activity and Expression of Histone Deacetylase 1 in Relation to Tumor Necrosis Factor-Alpha in Synovial Tissue of Rheumatoid Arthritis

Simultaneously, ROS disrupts insulin signaling in peripheral tissues by promoting IRS-1 serine phosphorylation and degrading phosphatidylinositol-3-kinase (PI3K)/Akt activation, leading to insulin resistance (Papaetis et al., 2025)