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Conversely, a return of fatigue or a dull complexion might signal a need for increased frequency or dosage

Mice were on C57BL/6 background (The Jackson Laboratory), fed either chow diet (Mouse Diet 9F, PharmaServ) or HFD (Research Diets, D12492)

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Further, it caused an increase in the activation of the Akt/GSK-3 pathway, indicating that IGF-1 could be a potential therapy for diabetic cardiomyocytes [9]