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While synthesized exclusively in the cytosol from its constituent amino acids, GSH is distributed in different compartments, including mitochondria where its concentration in the matrix equals that of the cytosol

As we age, glutathione production gradually declines: research consistently shows lower cellular glutathione concentrations in older adults compared to younger adults (Detcheverry et al., 2023)

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Low glutathione levels play a big role in triggering inflammation and autoimmune diseases