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However, it was found that estrogen did not inhibit reactive oxygen species(ROS)

Post hoc evaluations of the SUSTAIN 6 trial revealed that semaglutide markedly increased the incidence of diabetic retinopathy complications in individuals with a history of retinopathy, especially among insulin users, presumably due to the swift deterioration of pre-existing retinopathy following rapid glycemic control [91]

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202 The mechanism may be related to miR-3173-5p in exosomes secreted by CAFs, which is taken up by PDAC cells and inhibits ferroptosis by downregulating ACSL4 expression