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Series 2: 3-AR knock-out mice (the gene for the 3 receptor is knocked out) in the same design, to check whether 3 is necessary for the AOD-9604 effect
this is not an endorsement of nasal AOD-9604
However, this combination has not been formally studied
While structurally distinct from GLP-1 analogs, GLP-3 R is being investigated for its potential interactions with GLP receptor pathways and its role in energy balance, insulin sensitivity, and weight management
Six trials involving approximately 900 participants confirmed no treatment-related serious adverse events, no IGF-1 elevation, no cardiovascular events, and no immunogenic response
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