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Reported Effects Weight reduction (no diabetes): In REDEFINE 1, CagriSema 2.4 mg + 2.4 mg produced roughly 22.7% mean weight loss at 68 weeks (trial-product estimand), though this fell short of the ~25% Novo Nordisk had guided toward [1]

In addition, the induced photokilling effect is mainly dependent on the delivered light dose, at least within the tested values range

SGLT2is decrease plasma glucose levels through inhibition of renal glucose reabsorption in the proximal tubule, which results in increased glucose excretion by the kidneys

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Additionally, the data support its growing relevance in multi-agonist diabetes and obesity investigations