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Specialty Pharmacy Clinical Policy Bulletins: Aetna Non-Medicare Prescription Drug Plan
A key pharmacological challenge in the drug's design is balancing glucagon receptor activity to avoid unwanted increases in hepatic glucose production and net hyperglycaemia, which would counteract the glucose-lowering effects of GLP-1 and GIP agonism
Por lo tanto, la alternativa a los aGLP-1 seran los iSGLT-2, que adems de reducir los eventos MACE, disminuyen la mortalidad, tienen efectos beneficiosos en la prevencin de hospitalizacin por insuficiencia cardiaca y cuentan con ensayos especficos en insuficiencia cardiaca y ERC
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