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Administration of spironolactone, a selective MR antagonist, counteracted stress-induced mGlu2 suppression and the related development of depressive-like behavior, implicating rapid action of glucocorticoids via a receptor that is known to modulate glutamate release [20]

At least this is not the case when sudden repression of n-GPx4 expression is induced by n-GPx4 specific siRNA in developing embryos at midgestation

Malformations of cortical development and epilepsy

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Calcium-independent phospholipase A2 (iPLA2), a member of the PLA2 family, is a cytoplasmic protein with catalytic activity in the absence of calcium, and previous studies have shown that it is associated with metabolic disorders and inflammation [40]