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Metabolic profiling of dried blood spots from patients with HS identified significant features that suggest a glycolytic disturbance, including a decrease in glyceraldehyde-3-phosphate, a glycolytic intermediate, and 2,3-bisphosphoglycerate, which is produced via conversion of 1,3-bisphosphoglycerate, another metabolite of glycolysis, in the LueberingRapoport glycolytic shunt and is responsible for enhancing oxygen dissociation from hemoglobin (Hb) (4)

These are usually mild to moderate and improve over time as the body adjusts to the medication

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Analysis of covariance (ANCOVA) were used to study the statistical interaction between serum TMAO, L-carnitine levels, and sex on the main outcomes

We were just laughing as we were telling that episode