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Invega Sustenna/Xeplion/Invega Trinza/Trevicta (paliperidone) Disease area(s): Psychiatry Manufacturer(s): Johnson & Johnson 2024 Sales (USD): $4.22 billion Why it sold so well: In 2024, J&Js long-acting antipsychotic portfolio including Invega Sustenna, Xeplion, Invega Trinza and Trevicta registered global sales of $4.22 billion, reflecting a 2.6% year-over-year increase

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Consistently, when cells were subjected to cystine starvation in the presence of 6-diazo-5-oxo-L-norleucine (DON, a selective GGT inhibitor), there was a markedly higher accumulation of extracellular GSH (Fig