10.1371/journal.pone.0288523 83 JiangR.DuX.LnnerdalB
Pair semaglutide with resistance exercise and protein-centric nutrition to maintain muscle
Bromelain 19 references Nettis E, Napoli G, Ferrannini A, Tursi A
GLP-1, secreted by the intestine, brainstem, and pancreas, also exerts appetite-suppressing and gastric emptying-delaying effects on the hypothalamus
It is released within minutes of eating and does several important things simultaneously: Signals the hypothalamus to reduce hunger and increase satiety Stimulates insulin secretion from the pancreas (glucose-dependent so it does not cause hypoglycaemia on its own) Suppresses glucagon, which prevents excess glucose from being released by the liver Slows gastric emptying, so you stay full longer after meals May have cardioprotective and neuroprotective effects In people with insulin resistance, fatty liver, or type 2 diabetes, GLP-1 secretion is often impaired or the body's response to it is blunted