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Furthermore, imatinib induces ferroptosis in GIST by upregulating STUB1, which promotes K191 site-specific ubiquitination and degradation of GPX4, thereby disrupting the antioxidant defense, triggering lipid peroxidation, and leading to iron accumulation

Glutathione Pathways and Individual Genetic Predispositions Glutathione synthesis and metabolism depend on genes encoding key enzymes, including GCLC, GCLM, and GSS

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According to earlier research, the majority of RA patients responded to hydroxychloroquine (HCQ) treatment, as evidenced by improvements in joint score, pain, and grip strength

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