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SAM levels were decreased, but S-adenosylhomocysteine (AdoHcy, SAH) levels were elevated considerably, with global DNA hypomethylation observed in both heterozygotes and homozygotes 38

1 Faculty of Social Sciences, Tampere University, Tampere, Finland, 2 Health and Well-Being Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland, 3 Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, USA, 4 Department of Clinical Sciences, Lund University, Malm, Sweden, 5 Institute of Diabetes Research, Helmholtz Zentrum Mnchen, German Research Center for Environmental Health, Munich-Neuherberg, Germany, and Forschergruppe Diabetes, Technical University Munich, at Klinikum rechts der Isar, Munich, and Forschergruppe Diabetes, Munich-Neuherberg, Germany, 6 Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, USA

So, while present, they did not appear to be impacting the extent to which the drug was effective

Effect of chronic administration of resveratrol on cognitive performance during aging process in rats