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However, direct BDNF therapeutics face a fundamental challenge: the protein does not cross the blood-brain barrier

Relying on a single pathwaywhether it be just inflammation modulation or just ATP productionis often insufficient, which is why multi-target formulations like the Energize Plus Pure Pack are increasingly favored in clinical practice

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The primary analysis was based on the dose assigned at randomization (planned treatment) and included data censored for COVID-19-related discontinuations, while a sensitivity analysis used the actual maintenance dose received (actual treatment) with on-treatment data only